Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas.
Sönmez C, Wölfer J, Holling M, Brokinkel B, Stummer W, Wiendl H, Thomas C, Schulte-Mecklenbeck A, Grauer OM
Research article (journal) | Peer reviewedAbstract
memory T-cells after combined anti-CD3/anti-CD28 stimulation. Our data indicate that both blockade of inhibitory KIR and IL-2 triggering of tumor-derived NK-cells are necessary to enhance NK-cell responsiveness in GBM.
Details about the publication
Journal: Scientific Reports (Sci. Rep.)
Volume: 12
Issue: 1
Page range: 6769-6769
Status: Published
Release year: 2022 (26/05/2022)
Language in which the publication is written: English
Keywords: Glioblastoma; HLA-C Antigens; Humans; Interleukin-2; Killer Cells, Natural; Receptors, KIR
Authors from the University of Münster
| Holling, Markus | Clinic for Neurosurgery |
| Schulte-Mecklenbeck, Andreas | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |