Facile Fabrication of Silicon(IV)Phthalocyanine-Embedded Poly(vinyl alcohol)-Based Antibacterial and Antifouling Interfaces

Strokov K, Schäfer AH, Dobrindt U, Galstyan A

Abstract

Interest in the photodynamic inactivation of bacteria as an alternative method to antibiotic treatment continues to grow. Based on this approach, light-activated anti-infective interfaces could be fabricated via incorporation of photosensitizers into the polymer-based materials. In order to combine photobactericidal and antifouling functions, the choice of the carrier polymer is of particular significance: it should enable fast and effective conjugation of photosensitizer and reduce the formation of bioburden on the artificial material in a biological environment. This study reports one-pot fabrication and characterization of two silicon(IV)phthalocyanine /poly(vinyl alcohol)-based electrospun mats. The method relies on the thermal cross-linking of components by esterification using sebacic acid as a cross-linking agent. Fabricated flexible mats showed photosensitizer-dependent antibacterial photoactivity against different Gram-positive bacteria with low cytotoxic effects on human fibroblasts and were effective against bacterial attachment, as an early step toward future biofilm formation. This work provides practical guidelines in developing photoactive materials and interfaces that can be used in nonadhesive wound dressings, food packaging, water, and air filtration.