CRC 1009 A09 - Interplay of integrin-mediated adhension and MMP14-driven proteolysis in matrix barrier-breaking invadopodia of tumour cells
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
The molecular linkage between b1 integrins and MMP14 within invadopodia of melanoma cells will be disclosed at protein-chemical and cellular level. To study their functional linkage, integrin-dependent localization and activity of MMP14 within invadopodia will be analyzed. Inhibition of melanoma invasion by individually targeting MMP14 will be compared with an approach of dual targeting both b1 integrins and MMP14 with novel bifunctional integrin- and MMP14-targeting (BIMT) molecules at the cellular level. Translationally, BIMTs will be tested for their potential to inhibit melanoma invasion in chicken CAM and murine lung assay.
Keywords: Vascular Matrix Biology; Integrin-Matrix Interaction; Protein Chemistry
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-09/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Eble, Johannes | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Eble, Johannes | Institute of Physiological Chemistry and Pathobiochemistry |