CRC 1009 A11 - Myostatin-induced mechanisms of inflammatory bone and cartilage destruction by invasive fibroblast-like synoviocytes
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 1st Funding period
Description
To investigate the role of myostatin in inflammatory destruction of tissue barriers, we will compare the effects of myostatin deficiency and phamacological inhibition on joint destruction in three arthritis models (different TNF-dependent). In addition, fibroblast-specific myostatin and activin wil be investigated by using Col1α2-Cre mice. Moreover, we want to evaluate the involvement of myostatin/ activin-mediated Smad2 signaling on synovial fibroblast-mediated matrix degradation by investigating proliferation, migration, apoptosis, invasive capacity, adhesion molecules, matrix-degrading proteases as well as involved signaling pathways.
Keywords: Synovial inflammation
Website of the project: https://campus.uni-muenster.de/en/sfb-1009/projects/project-area-a/a-11/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Dankbar, Berno | Institute of Musculoskeletal Medicine (IMM) |
| Pap, Thomas | Institute of Musculoskeletal Medicine (IMM) |
Applicants from the University of Münster
| Dankbar, Berno | Institute of Musculoskeletal Medicine (IMM) |
| Pap, Thomas | Institute of Musculoskeletal Medicine (IMM) |