SFB TRR34 C14 - In vivo investigation of the role of adhesins in Staphylococcus aureus-induced infective endocarditis and development of a diagnostic imaging marker
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/07/2014 - 30/06/2018 | 1st Funding period
Description
Infective endocarditis (IE) caused by Staphylococcus aureus is mediated by a complex interplay of different adhesive molecules (adhesins). This project aims to elucidate the role of individual adhesins and their interactions. We will use non-invasive magnetic resonance imaging for longitudinal assessment of an in vivo mouse model, in which endocarditis is induced by different isogenic S. aureus mutants with knockout of individual adhesins. Based on the findings about essential adhesins, the second aim of this project is the development of a non-invasive imaging marker to specifically detect S. aureus-induced IE.
Keywords: S. aureus
Website of the project: http://www.staphaureus.org/
Funding identifier: TRR 34/C14
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Hörr, Verena | Clinic of Radiology |
Applicants from the University of Münster
| Faber, Cornelius Joachim | Clinic of Radiology |
Project partners outside the University of Münster
- Jena University Hospital (UKJ)Germany
Coordinating organisations outside the University of Münster
- University of GreifswaldGermany