CRC 1450 - C01: Metabolic priming of monocytes during inflammation in vivo

Basic data for this project

Type of projectSubproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster01/01/2025 - 31/12/2028 | 2nd Funding period

Description

Monocytes represent a heterogeneous population, which, depending on their stage of differentiation and activation, either can promote inflammation or induce resolution and repair. Time and duration of initial exogenous or endogenous triggers may determine such subsequent pro- or anti-inflammatory monocyte response patterns partially through shifts between glucose and lipid metabolism (metabolic priming). We aim at monitoring metabolism and spatio-temporal dynamics of monocytes and their functional contribution to inflammation through tracking of monocytes and dynamic metabolic imaging in murine models of autoimmunity-, hypoxia- and infection-driven inflammation.

KeywordsMonozyten; Entzündung
Website of the projecthttps://www.uni-muenster.de/CRC-inSight/research/area-C/C01.php
DFG-Gepris-IDhttps://gepris.dfg.de/gepris/projekt/452340249
Funding identifierSFB 1450/2, C01
Funder / funding scheme
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Roth, Johannes
Institute of Immunology
Schäfers, Michael
European Institute of Molecular Imaging (EIMI)

Applicants from the University of Münster

Roth, Johannes
Institute of Immunology
Schäfers, Michael
European Institute of Molecular Imaging (EIMI)

Research associates from the University of Münster

Dabel, Jennifer
European Institute of Molecular Imaging (EIMI)
Heiden, Nadine Christine
Clinic for Nuclear Medicine
Jansen, Lea
European Institute of Molecular Imaging (EIMI)
Jürgens, Ricarda
Institute of Immunology