SFB 1450 - B05: Mechanisms and visualisation of kidney injury-associated immunomodulatory responses affecting susceptibility to bacteria-induced pulmonary infection
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period
Description
This project aims to investigate the link between acute kidney injury (AKI) and nosocomial pneumonia, focusing on molecular mechanisms and visualization of inflammation. It will investigate the effects of AKI on uremic metabolites, cytokines, immune cell recruitment, and lung permeability. Due to preliminary findings suggesting the involvement of VE-PTP, we will explore its role in AKI-induced changes of the pulmonary vasculature alone and with subsequent lung infection. Additionally, we will develop a new strategy for activating opto-genetic proteins with chemiluminescence to visualize and target active sites of inflammation.
Keywords: Akutes Nierenversagen; nosokomiale Infektion
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-B/B05.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452339904
Funding identifier: SFB 1450/2, B05
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Block, Helena | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
| Wegner, Seraphine Valeska | Institute of Physiological Chemistry and Pathobiochemistry |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
Applicants from the University of Münster
| Block, Helena | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
| Wegner, Seraphine Valeska | Institute of Physiological Chemistry and Pathobiochemistry |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
Research associates from the University of Münster
| Ludwig, Nadine | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |