Regulation of photo triggered cytotoxicity in electrospun nanomaterials: role of photosensitizer binding mode and polymer identity

Galstyan A., Majiya H., Dobrindt U.

Zusammenfassung

Although electrospun nanomaterials containing photoactive dyes currently compete with the present state of art antimicrobial materials, relatively few structure-activity relationships have been established to identify the role of carrier polymer and photosensitizer binding mode on the performance of the materials. In this study scaffolds composed of poly(vinyl alcohol), polyacrylonitrile, poly(caprolactone), and tailor-made phthalocyanine-based photosensitizers are developed utilizing electrospinning as a simple, time and cost-effective method. The photoinduced activity of nanofibrous materials was characterizedin vitroagainstE. coliandB. subtilisas models for Gram-negative and Gram-positive bacteria respectively, as well as against bacteriophages phi6 and MS2 as models for enveloped and non-enveloped viruses respectively. For the first time, we show how polymer-specific properties affect antifouling and antimicrobial activity of the nanofibrous material, indicating that the most promising way to increase efficiency is likelyviamethods that focus on increasing the number of short, but strong and reversible bacteria-surface interactions.