Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions

Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A (2021)
In: Angewandte Chemie International Edition, 60(1)
Type of Publication: Research article (journal)

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, {Linard Matos} AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D (2021)
In: Molecular Cell, 2021
Type of Publication: Research article (journal)

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.

Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD (2020)
In: Cancer cell, 38(2)
Type of Publication: Research article (journal)

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B (2020)
In: Journal of Medicinal Chemistry, 63(22)
Type of Publication: Research article (journal)

Structure of membrane tethers and their role in fusion

Ungermann C, Kümmel D (2019)
In: Traffic (Copenhagen, Denmark), 20(7)
Type of Publication: Research article (journal)

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Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A (2021) In: Angewandte Chemie International Edition, 60(1) Type of Publication: Research article (journal)
Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein Hoffmann S, Terhorst TME, Singh RK, Kümmel D, Pietrokovski S, Mootz HD (2021) In: Chembiochem : a European journal of chemical biology, 22(2) Type of Publication: Research article (journal)
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, {Linard Matos} AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D (2021) In: Molecular Cell, 2021 Type of Publication: Research article (journal)
Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Hansmann P, Brückner A, Kiontke S, Berkenfeld B, Seebohm G, Brouillard P, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kümmel D (2020) In: Structure, 28(8) Type of Publication: Research article (journal)
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD (2020) In: Cancer cell, 38(2) Type of Publication: Research article (journal)
Comparison of the functional and structural characteristics of rare TSC2 variants with clinical and genetic findings {Dufner Almeida} LG, Nanhoe S, Zonta A, Hosseinzadeh M, Kom-Gortat R, Elfferich P, Schaaf G, Kenter A, Kümmel D, Migone N, Povey S, Ekong R, Nellist M (2020) In: Human Mutation, 41(4) Type of Publication: Research article (journal)
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B (2020) In: Journal of Medicinal Chemistry, 63(22) Type of Publication: Research article (journal)
A conserved and regulated mechanism drives endosomal Rab transition Langemeyer L, Borchers A, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C (2020) In: eLife, 9 Type of Publication: Research article (journal)
Structure of membrane tethers and their role in fusion Ungermann C, Kümmel D (2019) In: Traffic (Copenhagen, Denmark), 20(7) Type of Publication: Research article (journal)
Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure Gao J, Langemeyer L, Kümmel D, Reggiori F, Ungermann C (2018) In: eLife, 7 Type of Publication: Research article (journal)